Page 13 - 2016-2017 ХИЧЭЭЛИЙН ЖИЛД ХАМГААЛСАН ОУСИС-ИЙН МАГИСТРАНТУУДЫН СУДАЛГААНЫ ТӨСЛИЙН ХУРААНГУЙ 3-Р БОТЬ

Статистик боловсруулалтыг SPSS 17.0 программыг ашиглан гүйцэтгэнэ. Шаардагдах

параметрийн болон параметрийн бус тестүүдээр тооцооллыг хийн үр дүнг тооцно. APRI ба

FIB-4 индексийн оношлогооны ерөнхий үр дүнг ROC муруйн доорх утга ашиглан үнэлнэ.
ХҮЛЭЭГДЭЖ БУЙ ҮР ДҮН

В болон С вирусийн шалтгаантай элэгний архаг үрэвсэлтэй хүмүүст фиброзын зэргийг

фиброскан /FS/-аар тодорхойлж , улмаар APRI, FIB-4 индекстэй харьцуулж судалснаар
инвазив бус оношлогооны мэдрэг болон өвөрмөц чанарыг тодорхойлж элэгний архаг өвчний

тавиланд суурилсан оношлогооны зөвлөмж боловсруулна
Түлхүүр үг: Хүчин төгөлдөр байдлын судалгаа, APRI, FIB-4, фиброскан, мэдрэг чанар,

өвөрмөц чанар

ABSTRACT

BACKGROUND
Globally, it is estimated that approximately 185 million people are infected with HCV and 350,000

of them died each year. Also there are 240 million persons living with chronic HBV infection and
650,000 of them died every year. Today in Mongolia, It is reported that 113782 and 201387 people

are infected with HCV and HBV respectively.
Staging of hepatic fibrosis is essential prior to HCV and HBV treatment. Liver biopsy has long

been the golden standard for grading of hepatic fibrosis but it is invasive method and can have

capable risk of death (0.03-3%). There is thus a need for accurate noninvasive methods of
measuring the degree of liver fibrosis. For many counties, proposed approaches include transient

elastography which based on ultrasound, routine biochemical and hematologic tests and surrogate

serum fibrosis markers (APRI , FIB-4, FT ). However equipment of transient elastography are
expensive. Therefore it is recommended that APRI and FIB-4 index should be used instead of

elastography to determine fibrosis stage in resource – limited countries. With we have categorized
into resource limited countries, we have needs to further investigate these noninvasive methods.

OBJECTIVES

The aim of this study was to assess the performance of FibroScan in patients with chronic liver

disease associated with HCV and HBV, in comparison with APRI as well as FIB-4 index by
evaluating its specificity and sensitivity.

METHODS

Overall, consecutive 100 patients with chronic HCV and HBV infection and alanine
aminotransferase levels ≤ 2 х ULN were randomly chosen and prospectively studied at the

Department of Gastroenterology of the First Central Hospital. We have control group include 100

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